Are ERK and Wnt Fate d to Reinforce Calvarial Osteoblast Identity?
نویسندگان
چکیده
منابع مشابه
Fibronectin regulates calvarial osteoblast differentiation.
The secretion of fibronectin by differentiating osteoblasts and its accumulation at sites of osteogenesis suggest that fibronectin participates in bone formation. To test this directly, we determined whether fibronectin-cell interactions regulate progressive differentiation of cultured fetal rat calvarial osteoblasts. Spatial distributions of alpha 5 integrin subunit, fibronectin, osteopontin (...
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BACKGROUND Osteoblasts are bone forming cells that play an essential role in osteogenesis. The elucidation of the mechanisms that control osteoblast number is of major interest for the treatment of skeletal disorders characterized by abnormal bone formation. Canonical Wnt signalling plays an important role in the control of osteoblast proliferation, differentiation and survival. Recent studies ...
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Accumulating lines of evidence have indicated that hyperlipidemia not only is a well-established etiological factor for cardiovascular diseases (CVD), but also plays an active role in regulating bone metabolism. As a mixture of oxidized phospholipids derived from the oxidation of low density lipoprotein (LDL), oxidized 1-palmitoyl2-arachidonoyl-sn-glycero-3-phosphorylcholine (ox-PAPC) is report...
متن کاملInteractions between integrin receptors and fibronectin are required for calvarial osteoblast differentiation in vitro.
We previously showed that anti-fibronectin antibodies or soluble fibronectin fragments containing the central cell-binding domain inhibit formation of mineralized nodules by fetal calvarial osteoblasts in vitro. These findings suggest a critical role for fibronectin in osteoblast differentiation and morphogenesis. In this study we tested the hypothesis that fibronectin's effects on osteogenesis...
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Wnt activates the cytoplasmic Disheveled (Dsh) protein leading to inhibition of glycogen synthase kinase 3β (GSK3β) (Lee et al., 1999). Inhibition of GSK3β protects β-catenin against degradation by protein complexes, consisting of GSK3β, axin and adenomatous polyposis coli (APC) In the resting state, very little β-catenin is present in either the cytoplasm or the nucleus because of rapid degrad...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2021
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.2021.35.s1.02017